TUMOR MICROENVIRONMENT-BASED SIGNATURES DISTINGUISH INTRATUMORAL HETEROGENEITY, PROGNOSIS, AND IMMUNOGENOMIC FEATURES OF CLEAR CELL RENAL CELL CARCINOMA

Background: The tumor microenvironment (TME) performs a crucial function in the tumorigenesis and response to immunotherapies of clear cell renal cell carcinoma (ccRCC).However, a lack of recognized pre-clinical TME-based risk models poses a great challenge to investigating the risk factors correlated with prognosis and treatment responses for pati

Solving the robotic swarm coverage problem for an elliptical area has various applications for exploring novel environments.Solutions for this problem should cover a specified ellipse and seamlessly adapt to changing numbers of robots.Previous solutions used techniques such as formation control, vector fields, and neural networks.While these 156 te

Abstract Background Abnormal health anxiety, also called hypochondriasis, has been successfully treated by cognitive behaviour therapy (CBT) in patients recruited from primary care, but only one pilot trial has been carried out among those attending secondary medical clinics where health anxiety is likely to be more common and have a greater impact

Acute respiratory distress syndrome (ARDS), associated with high mortality SAW PALMETTO 500MG rate, affects up to 67% of hospitalized COVID-19 patients.Early evidence indicated that the pathogenesis of COVID-19 evoked ARDS is, at least partially, mediated by hyperinflammatory cytokine storm in which interleukin 6 (IL-6) plays an essential role.The